Correlation of transvaginal radiofrequency myolysis and estrogen, progesteron receptor in uterine myoma / 대한산부인과학회지

OBJECTIVE: The aim of this study was to investigate the changes in hormone receptors of myoma cells and volume decrement of myoma after radiofrequency myolysis. METHODS: From 2005 January to 2006 January, thirty patients who have had high-frequency myolysis were included in this study. Needle aspiration biopsy was done at the central portion of myoma pre- and 6 months post-operation. Radiofrequency myolysis were done for 20 minutes until discoloration of myoma was accomplished to 80%. The stain intensity of estrogen receptor (ER) and progesterone receptor (PR) was classified into "negative", "trace", "weak", "moderate" and "strong". RESULTS: The volume decrement was 96.4% in the group that showed trace to week stain intensity (under 50% stain intensity), but it decreased to 66.6% in the group that showed strong stain intensity (over 50%, moderate to strong)(P<0.05). ER showed moderate to strong positive response in 79% of patients before operation, but it showed negative to week response in 83% of patients after the operation. Also, PR showed moderate to strong positive response in 80% of patients before operation, but it showed negative to week response in 86% of patients after the operation. CONCLUSIONS: To coagulate entire myoma, we suggested that controlling the intensity of operation by lengthening the time or expanding the extent of operation was more effective in treatment, because the volume decrement of myoma was larger in case that ER and PR was under 50% before the operation.

Clinical symptom of premenstrual syndrome in Korean women acorrding to tissue mineral concentration / 대한산부인과학회지

OBJECTIVE: Premenstrual syndrome (PMS) is a disease with specific psychologic and physical symptoms on luteal phase. Its incidence is variable in 20~80%, but its cause is not definitely proved. Because progesterone and estrogen affect the balance of the body mineral, the alteration of progestorone and estrogen in the patients with PMS may effect the imbalance of tissue mineral, that can induce the specific symptoms of PMS. This study examines the relationship between symptoms of PMS and mineral count by tissue mineral test. METHODS: Women who volunteered for the tissue mineral test completed MMDQ questionnaire and checked blood test for Ca, Mg, Na, K, Cu, Zn. The tissue mineral test used the hair not treated within 3 weeks and not washed within 3 hours. The hair was send to TEI for the analysis. We used SPSS (14.0) for statistical analysis. RESULTS: The MMDQ score of the normal Mg group is significantly higher than the high Mg group (22.5+/-17.8 vs. 13.9+/-11.1), and the behavioral disorder score of the normal Na group is significantly lower than the low Na group (2.2+/-1.7 vs. 3.4+/-2.2). The MMDQ score of the normal Cu group is significantly lower than abnormal group (15.7+/-11.9 vs. 24.9+/-16.9). CONCLUSIONS: Total score of MMDQ showed difference according to magnesium and copper concentrations in tissue, and scores of behavioral disorder was affected by sodium concentration of tissue. Additional study about cause and effect relationship is required.

A case of adenofibroma of uterine cervix / 대한산부인과학회지

Adenofibromas of the uterine cervix, which are classified as benign tumors of mixed epithelium and mesenchymal cells, are extremely rare. Most common symptom is usually abnormal genital bleeding. It is very difficult to diagnose preoperatively. Recommended method of treatment is total hysterectomy, because it usually recurs. We experienced a case of adenofibroma of the uterine cervix with increased CA125, so report it with a review of the literature.

Radiofrequency myolysis: New conservative management of myoma / 대한산부인과학회지

OBJECTIVE: To evaluate the clinical efficacy of radiofrequency myolysis which is new developed uterine preserving management of myoma. METHODS: 17 patinets (27 myomas) who done radiofrequency myolysis between Oct. 2004-Dec. 2004 were participated this study. Preoperatively, Hemoglobin and subjective symptoms were checked and size of myoma was checked using ultrasonogram or computed tomogram (CT). Radiofrequency was applied to myoma for 10 to 40 minutes per one. Follow up sonogram or CT were done 7 days, 1 month, 2 month and 3 month after myolysis. RESULTS: Average age of patients was 42.7+/-8.6 (yr) and average size of myoma was 4.9+/-2.3 cm. We followed 27 nodules. After 3 months, reduction of volume was observed 65%, from 30% to 94%. 3 nodule, which was followed only 2 months, reduced by 46%. About subjective symptoms, 80% reduction was reported after 3 months (50-100%). Menorrhagia reduced 91% in average and pressure symptoms reduced 71% in average. No severe complication like bowel injury, bladder injury, infection and pulomonary embolism was not observed. Serious vaginal bleeding was reported for 3 patients, and their hemoglobin decreased from 10.8 mg/dL preoperatively to 8.7 mg/dL postopertively. CONCLUSION: Radiofrequency myolysis decreased myoma 65% in average. No serious complication were reported.